Dextran Methacryloyl (DexMA)

• Salesperson：Panpan Wang（EFL）

  Phone：15335258233

  Email：engforlife-mkt@efl-tech.com

  Foreign distributor：ANR Technologies Pte Ltd

Introduction

Dextran is a polysaccharide composed of glucose as a monosaccharide, and the glucose units are connected by glycosidic bonds. It can be divided into α-glucan and β-glucan according to the type of glucoside bond. The hydroxyl group on the side chain can be easily modified to obtain multifunctional active glucan derivatives. Compared with other polysaccharides, Dextran can be degraded slowly by biological enzymes in human body or split by dextranase of microorganisms in gastrointestinal tract.

Dextran Methacryloyl (DexMA) can be photo-crosslinked by introducing methacryloyl groups to dextran molecular chains. The DexMA products from EFL team (EFL-DexMA series) have stable physical and chemical properties through strict raw material screening and quality testing. It can be cured within 10 seconds with visible light irradiation. Due to excellent water solubility, good biosafety and resistance to non-specific protein adsorption, the material systems based DexMA have been widely used in the biomedical field, such as reducing the formation of blood clots in blood vessels, reducing blood viscosity and drug delivery.

Item

Application

Cell culture, bio 3D printing, tissue engineering, etc.

Storage

Dry kit: room temperature, 3 months; 4℃, 12 months; -20℃, 18 months.

HNMR

Fig 1. Synthesis reaction mechanism and NMR spectrum of DexMA

Rheological property

Fig 2. Rheological properties of DexMA-200K at different concentrations: (A) photocrosslinking process; (B) storage modulus G’after curing; (C, D) viscosity

Fig 3. Rheological properties of DexMA-500K at different concentrations: (A) photocrosslinking process; (B) storage modulus G’ after curing; (C, D) viscosity

Compressive property

Fig 4. Compressive properties of DexMA-200K/500K at different concentrations: (A, C) stress-strain curve; (B, D) compression modulus

Biocompatibility

Fig 5. DexMA hydrogel 3D cell (HUVECs) culture

3D printing performance

Fig 6. DexMA structure printed by photocuring bio-3D printer (EFL-BP-86 series)