Microneedle preparation solution

• Salesperson：Panpan Wang（EFL）

  Phone：15335258233

  Email：engforlife-mkt@efl-tech.com

  Foreign distributor：ANR Technologies Pte Ltd

Product introduction

Compared with traditional metal and silicon-based microneedles, EFL-MMA series microneedles based on biological materials such as hydrogels have the following advantages : a） has large drug loading and controllable drug controlled release effect ; b） needle body material is composed of polymer biomaterials, which has good biocompatibility and avoids potential damage to the skin caused by needle tip fracture. c） microneedles prepared by cross-linked polymer biomaterials can achieve subcutaneous swelling without dissolution, thereby increasing the drug loading of microneedles. A series of hydrogel products ( GelMA, HAMA, SilMA, gelatin, hyaluronic acid, polyvinyl alcohol and other commonly used biomaterials ) launched by the EFL team can be applied to the preparation of hydrogel microneedles. According to the long-term communication feedback between the EFL technical support team and users, we summarized the main difficulties in the preparation of hydrogel-based microneedles : a） microneedles are prone to shrinkage ; b） needle shape is poor ; c） tip mechanical strength is poor. In order to improve the experimental efficiency of researchers, the EFL team summarized and launched a complete set of solutions for hydrogel microneedle preparation ( microneedle mold + vacuum defoaming device + hydrogel material ).

Item（Mold of Microneedle）

According to the long-term communication feedback between the EFL technical support team and the users, the EFL team selected four commonly used microneedle molds. The specific specifications are as follows :

Item（Vacuum defoaming device）

The EFL-VDM-001 microneedle defoaming device can assist users to better eliminate the influence of bubbles on the formation of microneedles during the preparation of microneedles. The device includes a）oil-free vacuum pump ; b ) 500ml sealed vacuum tank( with vacuum gauge ). 

Microneedle preparation process

Microneedle characterization

HAMA photocurable swelling hydrogel microneedles ( A : needle height 500μm, needle bottom diameter 270μm, patch diameter 17.5mm ; B, C : needle height 600μm, needle bottom diameter 270μm, patch : 14.5mmX14.5mm ; ).

The SEM images of microneedles with needle heights of 500μm and 600μm, respectively.

Microneedle CLSM images ( tip-rhodamine B labeling, substrate-fluorescein labeling ) with needle heights of 500μm and 600μm, respectively.

Stress-displacement curves of different microneedles.